1
SOLUBILITY / SOLUTION STABILITY: Nifedipine can be dissolved in DMSO at 50 mg/ml 4
0058 g/L; pH 7, 0
8 It is almost completely absorbed in the gastrointestinal The solubility of nifedipine (NIF) in binary mixtures of ethanol (EtOH) + water and propylene glycol (PG) + water at 293
18
It has a molecular weight of 346
Nifedipine extended-release tablets consist of an external coat and an internal core
The observed partition coefficient of N was determined using n -octanol/phosphate buffer pH 7 at 37°C, and found to give a log Koct of 3
Nifedipine (NDP) is a typical poorly water-soluble drug that is pharmaceutically used as a calcium channel blocker for the treatment of cardiovascular diseases []
In order to enhance these characteristics, preparation of nifedipine nanoparticles has been achieved using high pressure homogenization
1997), complexation with β-cyclodextrins (Acartürk, Kislal The nifedipine solid dispersion was prepared by rotary evapo-ration
SEM, XRD, DSC, and FT-IR were used for characterization of the solid dispersion
Add a small portion of Syr-Spend SF PH4 Cherry Flavored to the powder and mix well to form a smooth paste
In order to enhance these characteristics, preparation of nifedipine nanoparticles has been achieved PAMAM dendrimers have significantly enhanced the water solubility of nifedipine
3
Nifedipine extended release tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration
0039)
nifedipine Nifedipine is a poorly water-soluble drug and its oral
The stoichiometry of the nifedipine-GA inclusion complex below critical micelle concentration (~1 mM) was calculated as 1:2 using Job plot measurement
3
The phase solubility curve of nifedipine in the presence of β-CD is shown in Figure 1
The mean particle size and zeta potential of the NI-lipid 10
In this study, the solubilizing effect of 4-sulphonic calix[n]arenes on the poorly water soluble drug nifedipine was investigated
3
Nifedipine extended-release tablets are formulated as a once-a-day controlled-release tablet for oral administration designed to deliver 30, 60, or 90 mg of nifedipine
All the solid dispersions of nifedipine were prepared by the fusion method using nicotinamide and 4 different water-solu
1) is a calcium channel blocking agent
15451538
Nifedipine is a poorly water-soluble of the important factors for the enhancement of absorption and obtaining adequate oral bioavailability (Hiroyuki et al
References
Committee for Medicinal Products for Human Use (CHMP); Guideline on the Environmental the Pharmaceutical industry is related to strategies that improve the water solubility of drugs
From the first extensive review (Chiou and Riegelman, 1971, Ford, 1986), number of papers on studies comprising variety of carriers, drug/carrier The solubility of nifedipine (NIF) in binary mixtures of ethanol (EtOH) + water and propylene glycol (PG) + water at 293
0058 g/L; pH 7, 0
The solubility of NIF in EtOH + water mixtures have a maximum at 0
Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol
Nifedipine is extensively metabolized to highly water soluble, inactive metabolites accounting for 60% to 80% of the dose excreted in the urine
Introduction Together with membrane permeability, the solubility/dissolution behaviour of a drug is a key determinant to its oral bioavailability
Nifedipine, a antihypertensive agent, is practically insoluble in water
In this study, the solubilizing effect of 4-sulphonic calix[n]arenes on the poorly water soluble drug nifedipine was investigated
Poorly water-soluble drugs such as nifedipine (NIF) (∼20
In this study, the solubilizing effect of 4-sulphonic calix[n]arenes on the poorly water soluble drug nifedipine was investigated
Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol
It has a molecular weight of 346
Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent TGA results showed that HPMCAS-HF bound water at higher temperatures than PEG 1450 (p<0
Nifedipine has an aromatic structure (shown in Figure 1) and is highly crystalline, its solubility in water is very low and is classified in the biopharmaceutics classification system (BCS) as a type II drug
Nifedipine (1,4-Dihydro-2,6-dimethyl-4- (2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester); ≥ 98% HPLC, powder; This compound is also offered as part of Sigma′
This is associated with poor dissolution characteristics and, therefore, with poor
4 In summary, for aqueous based media, an excess amount of nifedipine was added to 2 mL of medium, dwelled for 24 hours at a shaking water bath
Inert ingredients are: colloidal silicon dioxide Nifedipine poorly soluble in water
Diseases like angina, asthma, epilepsy etc
4-Sulphonic calix[n]arenes are water-soluble phenolic cyclooligomers that form complexes with neutral molecules such as nifedipine
Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine