Herpetic skin lesions are common in neonatal encephalitis
Neonatal HSV disease: IV: Birth to 3 mo: 60 mg/kg per day in 3 divided doses for 14–21 days
The original studies of acyclovir in neonatal HSV infections used a dosing regimen of 30 mg/kg/day
current approved dosing regimen of acyclovir for neonatal HSV infection is 10 mg/kg every 8 hours for 10 days
After this regimen, infants with CNS disease are given oral acyclovir 300 mg/m 2
Usual Pediatric Dose for Herpes Simplex - Mucocutaneous/Immunocompetent Host
A high dose of acyclovir was not associated with a better outcome in HSE patients
It is in the antivirals class of drugs
In older infants and children with HSV encephalitis, the recommended dose is 30 mg/kg/day for 14 to 21 days
Therefore, empirically, it is recommended that physicians start all patients with suspected encephalitis on acyclovir
no kissing if labial/oral herpes, and covering of lesions if
Safety and efficacy of high-dose acyclovir in the management of neonatal herpes simplex virus infections
For herpes simplex, use normal oral dose every 12 hours if eGFR less than 10 mL/minute/1
METHODS
recommended 10 mg/kg of body weight every 8 h (q8h) for neonates, while Blum et al
The consequences of neonatal herpes simplex virus (HSV) infection can be severe
Mucocutaneous herpes simplex (immunocompromised): 5mg/kg every 8 hours for 7 days
most common causes of encephalitis
If acyclovir is not available, use ganciclovir IV 6 mg/kg/dose every 12 hours
In newborn infants, herpes simplex virus (HSV) infection can manifest as: (1) disseminated disease involving multiple organs, most prominently liver and lungs, and in 60% to 75% of cases also involving the central nervous system (CNS); (2) localized CNS disease, with or without skin, eye, or mouth involvement (CNS disease); or (3) disease localized to the