Heart failure (HF) is a leading cause of morbidity and mortality globally
Lasix absorption is much less predictable, and the presence of food may delay the response
Admission for worsening HF was reduced by diuretics compared with placebo in two trials with a total of 169 patients (OR 0
Question Does torsemide improve mortality and hospitalization outcomes at 12 months compared with furosemide in either de novo heart failure (HF) or worsening chronic HF (WHF)?
Loop diuretics are essential in the treatment of patients with heart failure (HF) who develop congestion
Mentz RJ, Anstrom KJ, Eisenstein EL, Sapp S, Greene SJ, Morgan S, Testani JM, Harrington AH, Sachdev V, Ketema F, et al; TRANSFORM-HF Investigators
1% in the torsemide group and 26
To the Editor, Heart failure (HF) is a leading cause of morbidity and mortality globally
The TRANSFORM (Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure) trial randomised 2859 patients to either oral furosemide or torsemide at the point of discharge following admission with HF, the dose of which was determined by the treating clinician [65•]
In this article, we will explore various aspects of Furosemide Lasix, including Patients receiving torsemide were more likely to be female and had more comorbidities compared with furosemide-treated patients
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17 A meta-analysis of studies assessing mortality with torsemide vs furosemide demonstrated a nominal reduction in death events of more than 20% with torsemide
However, torsemide did not provide signi cant bene ts in reducing mortality or rehospitali-fi fi zation rates for HF or CVD compared with furosemide
Diuretic resistance implies a failure to increase fluid and sodium (Na +) output sufficiently to relieve volume overload, edema, or congestion, despite escalating doses of a loop diuretic to a ceiling level (80 mg of furosemide once or twice daily or greater in those with reduced glomerular filtration rate or heart failure)
[1,2] It approximately affects 1% to 2% of the adult population in developed countries, rising to greater than or equal to 10% of people greater than 70 years of age
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